The white chocolate colonoscopy prep bar Colonar圜oncepts “That is a big leap that will take decades of studying to figure out.” “Laxatives do change the microbiome, but we don’t have data to suggest that those changes caused by the laxatives are the same changes that we see in the study of dementia,” said Rezaie, who was not involved in the research.
Ali Rezaie, director of the GI Motility Program at Cedars-Sinai Medical Center, said that he’s skeptical of the findings and that the study lacks one main component needed to accurately draw an association between regular laxative use and dementia: enough data. The study’s limitations include that patient data was self-reported and could have been inaccurately noted, and that there was limited information on possible confounders like fiber intake and severity of constipation.ĭr. Laxatives may also disrupt the epithelial barrier, which regulates nutrient absorption and helps deliver necessary substances to the central nervous system. An osmotic laxative may also increase the production of intestinal toxins, they wrote. They said that an osmotic laxative has a lasting impact on the microbiome and could affect the production of neurotransmitters needed for normal cognitive function. tampatra/Adobe Stockĭementia risk rises if you live with chronic pain, study says African American person waking up on bed in bedroom at home in early morning, suffering from backache or cramp. The researchers offered one explanation for the finding, which begins with the composition of the microbiome, the trillions of microorganisms that live in the gut.
“Further study is absolutely warranted to make a definitive impact on clinical practice,” said Isaacson, who was not involved in the study. Richard Isaacson, a preventative neurologist at the institute for Neurodegenerative Diseases of Florida, says the findings are interesting but only speculative. “Regular use of laxatives was associated with a higher risk of all-cause dementia, particularly in those who used multiple laxative types or osmotic laxative,” they wrote in the study.ĭementia was diagnosed in 1.3% of the participants who regularly used laxatives and 0.4% of those who didn’t report regular laxative use.ĭr. The researchers found that 2,187 participants had a diagnosis of all-cause dementia, which includes Alzheimer’s disease and vascular dementia, by the end of the study period. Study presents unexpected - and complicated - findings on link between alcohol and dementia “The prevalence of stroke, high blood pressure, depression, poor overall self-health rating, and the uptake of calcium channel blockers, statins, and steroid drugs were higher in regular than non-regular users,” the study says.Ĭlose up man holding glass with alcohol in hand on wooden table at home, drinking whiskey alone, customer sitting at bar counter, problem with alcoholic beverages concept fizkes/Adobe Stock These regular users were more likely to be women, have less education, have a chronic illness, and regularly take anticholinergic and opioid drugs. About 3.6% of the participants reported using laxatives most days of the week for the previous four weeks. At the start, the study authors identified the participants’ health status and lifestyle factors, including their exposure to over-the-counter laxatives. The study included about 10 years of self-reported data from 476,219 adults ages 40 and 69 in the UK. The other major kind, stimulant laxatives, increases muscle contractions along the stool mass. The study, published Wednesday in the American Academy of Neurology’s medical journal, Neurology, suggests that a potential dementia link is strongest with osmotic laxatives, which draw water into stool to make it softer and easier to pass. Not just prunes: foods to help you get regular
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